High levels of hyperuricaemia which seemed to produce uniform precipitation of crystals in the joints and surrounding soft tissue, leading to clinical manifestations of gout.
Slowdown in part caused by genetic factors. If your parents have arthritis, the chance of hitting the 20% decline. Eating habits and lifestyle, such as excessive use of organs and other foods high in purines also increase the risk of gout. The possibility of an attack of gout before age 30 or premenopausal women showed a defective inheritance, kidney disease or drug or enzyme poisoning toxins such as ethanol or lead.
There are four stages of gout. If you have arthritis, it is important to know the four steps to develop a sense of their situation. With proper handling of uric acid, prevent the incidence of crippling the last step.
Step 1: asymptomatic hyperuricemia
High levels of hyperuricaemia in the body, but does not cause symptoms. Most people in this stage are aware of their condition after a blood test that measures the amount of uric acid in the blood.
Treatment is usually not necessary at this time. Patients with high levels of hyperuricaemia in the years before the first attack. The risk of stroke increases in the levels of hyperuricaemia . It is suitable for treatment at this stage aims to reduce levels of hyperuricaemia in the body.
Step 2: attack of acute arthritis
Prolonged hyperuricemia accumulation of uric acid crystals of sodium in the joints. Crystal then stimulate the release of various inflammatory mediators that cause an acute attack. Patients often wake up at night because of pain and swelling. At this stage of the arthritic symptoms of pain and inflammation that affects the joints become warm and tender touch, redness or bruising, itching and flaking after the pain subsided.
Intensity of pain varies from mild to severe pain, decreased joint affected. A systemic symptoms such as fever, chills and fatigue may also occur and is caused by several inflammatory mediators, leaked into the venous circulation. The pain will disappear within 30 to 10 days without treatment.
Step 3: Critical areas
This episode when free from symptoms of arthritis. In most people live, this time from six months to two years after the first attack of gout. In other cases, no symptoms last 50-10 years.
This is the best time to prevent future attacks. Arthritis is clinically inactive, but again and again to contract the disease if not controlled uric acid. Highest levels of uric acid, a short break the next attack.
Step 4: Advanced arthritis
At the end of the drop continues symptoms, and symptoms. Total deposits of uric acid crystals in the cartilage, tendons and soft tissues, and a layer of large bones. Patients often have different symptoms such as stiffness, limitation of motion, joint pain is wrapped with white pus in the region, joint pain at the same time in different parts of the body, and worsening of kidney function. In patients with arthritis are likely to get kidney stones more often than others.
This step is called the proposals tofu. A urate tofu (plural tophi) crystals deposited in many soft tissues, which can damage the soft tissues and persendian.Tofus develop most often on the elbows, knees, feet, Achilles tendons and, more rarely, the ear.